[{"data":1,"prerenderedAt":60},["ShallowReactive",2],{"post-perdida-volumen-cerebral-terapia-antiamiloide":3},{"id":4,"documentId":5,"Title":6,"Author":7,"URL":8,"Publication_date":9,"Hashtags":10,"Content":11,"createdAt":12,"updatedAt":13,"publishedAt":14,"Summary":15,"title_Url":16,"specialty":17,"Image":18},240,"e16zmkobuxs74br986fezjcd","Tejido ausente, datos ausentes: Resolviendo la pérdida de volumen cerebral causada por terapias anti-amiloide","Francesca Alves","https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1004880","2026-01-20","#Neurologia #Alzheimer #InvestigacionClinica #SaludMental #Medicina","por Francesca Alves, Scott Ayton\n\nLos fármacos anti-amiloide desaceleran modestamente la progresión de la enfermedad de Alzheimer, aunque existe incertidumbre sobre la sostenibilidad de sus beneficios, particularmente debido a que provocan una aceleración paradójica en los cambios de volumen cerebral. En este artículo, examinamos las posibles explicaciones para estos cambios de volumen y abogamos por una divulgación transparente de los datos de los ensayos clínicos.","2026-01-27T01:48:12.681Z","2026-01-27T01:48:12.981Z","2026-01-27T01:48:12.996Z","¿Cómo afectan realmente las terapias anti-amiloide al cerebro de pacientes con Alzheimer? Nuevas evidencias sugieren una paradoja: una modesta desaceleración en la progresión de la enfermedad con un aumento en la pérdida de volumen cerebral. Este análisis crítico pide una mayor transparencia y estudio sobre los datos de los ensayos clínicos para entender completamente estas dinámicas.","perdida-volumen-cerebral-terapia-antiamiloide","Neurología",{"id":19,"documentId":20,"name":21,"alternativeText":22,"caption":22,"width":23,"height":23,"formats":24,"hash":55,"ext":28,"mime":29,"size":56,"url":57,"previewUrl":22,"provider":58,"provider_metadata":22,"createdAt":59,"updatedAt":59,"publishedAt":59},83,"o64aswcatkt8jok64v746moz","image.png",null,1024,{"thumbnail":25,"small":34,"medium":41,"large":48},{"name":26,"hash":27,"ext":28,"mime":29,"path":22,"width":30,"height":30,"size":31,"sizeInBytes":32,"url":33},"thumbnail_image.png","thumbnail_image_4a1dc6f10c",".png","image/png",156,45.9,45902,"/uploads/thumbnail_image_4a1dc6f10c.png",{"name":35,"hash":36,"ext":28,"mime":29,"path":22,"width":37,"height":37,"size":38,"sizeInBytes":39,"url":40},"small_image.png","small_image_4a1dc6f10c",500,367.24,367237,"/uploads/small_image_4a1dc6f10c.png",{"name":42,"hash":43,"ext":28,"mime":29,"path":22,"width":44,"height":44,"size":45,"sizeInBytes":46,"url":47},"medium_image.png","medium_image_4a1dc6f10c",750,774.6,774596,"/uploads/medium_image_4a1dc6f10c.png",{"name":49,"hash":50,"ext":28,"mime":29,"path":22,"width":51,"height":51,"size":52,"sizeInBytes":53,"url":54},"large_image.png","large_image_4a1dc6f10c",1000,1230.89,1230891,"/uploads/large_image_4a1dc6f10c.png","image_4a1dc6f10c",377,"/uploads/image_4a1dc6f10c.png","local","2026-01-27T01:48:12.249Z",1777183248727]